Scientists are excited about LL-37 as it may be the door to new avenues of combating infections and addressing health problems. This article argues that LL-37 helps maintain your safety and health.
What is Cathelicidin LL-37 Peptide?
Antimicrobial peptides (AMPs) are naturally produced antimicrobials that are part of the body and are primarily located in protective layers, such as skin, mucus, and tears.
The special thing about LL-37 is that it does more than just fight germs. It can kill a wide range of bacteria, viruses, and fungi. It guides immune cells to the exact place where they are needed.
Research suggests that it may be developed into a novel treatment and has high potential to become a drug for use in various diseases. (Adam et al. 2016)
Here’s how LL-37 makes it happen.
Part 2: Cathelicidin LL-37 Peptide Mechanism of Action
The treatment of bacteria is becoming increasingly difficult, as most bacteria have now developed resistance to antibiotics.
Cathelicidin LL-37 Peptide is one of the most crucial AMPs in humans. It is kept in some immune cells in an inactive state known as hCAP18.
Here’s how LL-37 works:
- It gets attached to the surface of bacteria, viruses, or fungi.
- It disrupts their wall of protection (the membrane).
- It may sometimes create tiny holes (pores), and at other times, it may form a surface-like texture.
- The germs rupture and perish, which prevents the spread of the infection. (Shahmiri et al. 2016)
The structure of LL-37 is unique: one part of it is hydrophilic, while another part has a positive charge. This facilitates the adherence of LL-37 to the negatively charged walls of bacteria.
Part 3: The Role of Cathelicidin LL-37 Peptide
LL-37 is not merely a jack-of-all-purpose molecule, and it has numerous hats in your body. This small peptide works 24/7 to defend and repair, whether it is fighting off harmful germs or maintaining your immune system in balance.
We must know its two most significant functions.
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LL-37 as an Antimicrobial Shield
Cathelicidin LL-37 Peptide is a kind of an inner natural shield. It aids in combating various types of germs and promotes healing.
- Kills Bacteria: LL-37 can destroy the walls of the dangerous bacteria. Scientists declare that it is effective in several ways: it covers the surface in the form of a carpet, creates tiny holes, and bends the wall until it collapses.
- Protects against Viruses: It prevents viruses from easily accessing your cells and causing illness.
- Prevents Fungi: LL-37 also protects against fungi, including yeast, which can cause an infection.
- Helps Healing: LL-37 is not only a germ killer, but also helps in healing. It promotes the healing process of wounds, minimizes the detrimental swelling, and directs the immune cells to their destination. (Khurshid et al. 2017)
Due to these abilities, scientists are attempting to develop LL-37-based medicines to treat skin issues, heal wounds, and even prevent bacterial adherence to medical implants.
LL-37 is a defender and a curer; hence, it is among the most powerful natural protectors of the body.
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